SL-164

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SL-164 is a synthetic derivative of the quinazoline group. The substance SL-164 is a structural analogue of a number of substances, such as methaqualone, methyl methaqualone and afloqualone. SL-164 was developed in the 60s of the XX century along with other representatives of the group with sedative and hypnotic properties. The substance is mentioned in US3651230A, where its synthesis scheme, physical properties are given.

Synonyms:N/A
CAS:N/A
Formula:C16H12Cl2N2O
Molecular weight:319.18 g/mol
Compound purity:≥98%
IUPAC:5-chloro-3-(4-chloro-2-methylphenyl)-2-methylquinazolin-4-one
According to it's properties, SL-164 refers to anxiolytics, as well as to drugs with sedative/hypnotic effects. According to a 1969 study, SL-164 proved to be a very effective tranquilizer with low toxicity. During the study, the toxicity and properties of the substance were compared with meprobamate, chlordiazepoxide and methaqualone. By sedative properties, SL-164 was closer to chlordiazepoxide, however, unlike the latter, a higher therapeutic index was noted for SL-164. Despite the similarity of the structure with methaqualone, the authors noted a serious difference in their properties, because SL-164 is characterized by low toxicity, an almost complete absence of sleeping pills and strong sedative effects.
 
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