3-HO-PCP

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3-Hydroxyphencyclidine (commonly known as 3-HO-PCP) is a dissociative research chemical of the arylcyclohexylamine class. 3-Hydroxyphencyclidine is a novel dissociative compound known for its dissociation, hallucinogenic and euphoric effects. In addition to its main role as an NMDA receptor antagonist, results have also shown that this dissociative compound has significant affinity for the μ-opioid receptor.

Synonyms:3-Hydroxyphencyclidine; Hydroxyphencyclidine; 3-OH-PCP; PCP-3-OH; 3-Hydroxy-PCP
CAS:79787-43-2
Formula:C17H25NO
Molecular weight:259.39 g/mol
Compound purity:≥98%
IUPAC:3-(1-Piperidin-1-ylcyclohexyl)phenol
3-HO-PCP was first synthesized in 1978 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives. It was further explored alongside PCP in the 1980s, where it was discovered to possess μ-opioid agonist activity in animal models. Like other substances of its class, particularly methoxetamine (MXE), phencyclidine (PCP), and 3-MeO-PCE, it is known to primarily induce a state referred to as “dissociative anesthesia”, albeit the extent to which this occurs has been reported to be highly dose-dependent and variable in its effects. It is unknown whether the studied opioid properties in animal models applies to humans, with some early reports suggesting that it does not. There are also reports that suggest this compound may produce more physical side effects such as muscle soreness and flu-like symptoms during or shortly after administration. This suggests it may be uniquely more dangerous or toxic than related dissociatives, particularly at higher doses.
 
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