Vardenafil's indications/contraindications are the same as with other PDE5 inhibitors; it's worked like sildenafil citrate (Viagra) and tadalafil (Cialis),but it's worked somewhat longer than sildenafil's. Also it can be effective in the treatment of premature ejaculation, where it may significantly increase the time from penetration to ejaculation. Adverse reactions are the same as with other PDE5 inhibitors (nausea; the infrequent side effects are abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial edema, hypotension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, and priapism).