5F-AKB48

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5F-AKB48 (also known as 5F-APINACA) is an indazole-based synthetic cannabinoid that acts as a potent agonist for the CB1 and CB2 cannabinoid receptors. It was first identified in South Korea. 5F-AKB48 differs structurally from AKB48 by having fluorine at the terminal carbon of the pentyl chain. While its molecular structure differs only slightly from that of AKB48 by the addition of fluorine at the terminal carbon of the pentyl chain, the effects are reported to be significantly more potent than that of the parent compound.

Synonyms:5F-APINACA; 5-fluoro APINACA; 5-fluoro AKB48
CAS:1400742-13-3
Formula:C23H30FN3O
Molecular weight:383.51 g/mol
Compound purity:≥98%
IUPAC:N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide
This chemical is sometimes referred to as 5F-APINACA and is more formally known as N-((3s,5s,7s)-adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide. It is a member of the synthetic cannabinoid class, and early tests indicate that it binds to the peripheral CB2 cannabinoid receptors. Since it is so new to the research industry, however, there is still much that can be learned about it. Structurally it closely resembles cannabinoid compounds from patent WO 2003/035005 but with a 5-fluoropentyl chain on the indazole 1-position, and 5F-APINACA falls within the claims of this patent, as despite not being disclosed as an example, it is very similar to the corresponding pentanenitrile and 4-chlorobutyl compounds. While the physiological properties of this compound are not known, quinolones with adamantyl-carboxamide moieties display high affinity for the peripheral CB2 receptor but greatly reduced affinity for the central CB1 receptor. Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. 5F-AKB48 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids. This product is intended for research and forensic applications.
 
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